L-5-Methyltetrahydrofolate Calcium Nutritional Supplement High Quality CAS No 151533-22-1

• Customization: Available
• Function: Vitamins and Minerals Deficiency Drug, Antibiotic and Antimicrobial Agents
• Certification: GMP
• Model NO.: L-5-Methyltetrahydrofolate calcium
• Type: Analysis reagent
• State: Liquid
• Volatile: Not Volatile
• CAS: 151533-22-1
• Transport Package: 25kg
• Specification: 99%
• Trademark: langyue
• Origin: Hunan
• HS Code: 2901
• Production Capacity: 30 Tons/Year

Product Description

Product Information:

Product Name:	Levomefolate calcium
Synonyms:	(S)-2-(4-((((S)-2-AMino-5-Methyl-4-oxo-3,4,5,6,7,8-hexahydropteridin-6-yl)Methyl)aMino)benzaMido)pentanedioic acid, calciuM salt; L-5- Methyl leucovorin;Calcium (S)-2-(4-((((S)-2-amino-5-methyl-4-oxo-3,4,5,6,7,8-hexahydropteridin-6-yl)methyl)amino; CALCIUML-5-METHYLTETRAHYDROFOLATE; (6S)-N-[4-(2-Amino-1,4,5,6,7,8,-hexahydro-5-methyl-4-oxo-6-pteridinylmethylamino)benzoyl]-L-glutaminsure, Calciumsalz (1:1); Calcium levomefolate;L-5-Methyltetrahydrofolate calcium;METHYL FOLATE CALCIUM SALT(METAFOLIN)(P)
CAS:	151533-22-1
MF:	C20H27CaN7O6
MW:	501.56
EINECS:	691-636-3

Levomefolate calcium is an organic calcium salt of (6S)-5-methyltetrahydrofolic acid. It has a role as an antidepressant. It
contains a (6S)-5-methyltetrahydrofolate(2-).

ITEM		SPECIFICATION	RESULT	Test method
Appearance		White to light yellow crystalline powder	Complies	Visual
Identification	IR	IR should be identical with that of reference	Complies	USP43
	Calcium	A 5-mg/mL solution meets the requirements
	HPLC	The retention time of the major peak in the chromatograme of Assay preparation corresponds to that in the chromatograme of the standard preparation, as obtained in the Assay
Elemental impuritiys	Boron	≤50PPM	Complies	USP43
	Platinum	≤10PPM	Complies
	Arsenic	≤1.5PPM	Complies
	Cadmium	≤0.5PPM	Complies
	Lead	≤1.0PPM	Complies
	Hg	≤1.5PPM	Complies
Residual solvent		Ethanol≤0.5% 2-Propanol≤0.5%	Complies	USP43
Related compounds	4-Aminobenzoylgluta mic acid	≤0.5%	ND	USP43
	4a-Hydroxy-5-methyl-tetrahydrofolic acid	≤1.0%	ND
	(6R)-Mefox	/	ND
	(6s)-Mefox	≤1.0%(sum of 6R and 6S)	0.31%
	Tetrahydrofolic acid	≤0.5%	ND
	7,8-Dihydrofolic acid	≤0.5%	ND
	Folic acid	≤0.5%	ND
	5,10-Methylenetetrah-yd rofolic acid	≤0.5%	ND
	5-Methyltetrahydrop-teroic acid	≤0.5%	ND
	Dimethyltetrahydrofolic acid	≤0.15%	ND
	Total Impurites	≤2.5%	1.21%
D-5-Methylfolate		≤1.0%	0.24%	USP43
Calcium (on the anhydrous and solvent-free basis)		7.0%-8.5%	7.8%	USP43
Water determination		6%-17.0%	16.3%	Karl Fischer
Particle size		90% pass 80 mesh	Complies	Sieve
Chloride		≤0.5%	Complies	USP43
Heavy metals		≤10ppm	Complies	USP43
Total microbacterial count		≤100CFU/g	Complies	CP2015
Yeast &Mould		≤10CFU/g	Complies	CP2015
Escherichia Coli presence		Negative	Negative	CP2015
Salmonella		Negative	Negative	CP2015
Staphylococcus aureus		Negative	Negative	CP2015
P. aeruginosa		Negative	Negative	CP2015
Candida albicans		Negative	Negative	CP2015
Clostridia		Negative	Negative	CP2015
Calcium L-5-methyltetrahydrofolate		95.0%-102.0%	98.9%	USP43
L-5-methyltetrahydrofolate		≥85.0%	90.1%	USP43
Conclusion		The results conforms with the USP43 standard.

 

Uses:

• Mainly for folic acid antagonists (such as methotrexate, pyrimethamine, benzyl cefalexin and trimethoprim) antidote, it's usually used for prevention of methotrexate dose or overdose treatment caused severe toxic effects.
• Folic acid treatment of the following diseases, such as inflammatory diarrhea and protein-energy malnutrition (poor nutrition), pregnancy or infancy megaloblastic anemia caused by poor.
• As adjuvant therapy for colon cancer, rectal cancer.
• Combined with 5-FU and treatment of digestive tract tumors or other 5-FU-sensitive tumors. High-dose CF used in conjunction with 5-FU (LF), the basic programme is currently the treatment of colon and rectal cancer.
• For children with leukemia, lymphoma, and osteosarcoma, such as high dose MTX treatment when rescued.  

 

Quality Control: 

We have advanced precision instruments and equipment ,so we can independently control product content, pesticide residue, physical and chemical properties, microorganisms, heavy metals and other quality indicators. Our goal is zero complaints.



We have our own plant base. Weeding by hand, no pesticides or herbicides used. Control quality from the source.




Packaging:
The product is packed in 25kg or 10kg fiber drum.
It should be stored in its original packing or in a suitable sealed container and kept in a clean and dry place. Storage conditions should preferably be a sheltered environment with limited temperature variations and low humidity levels. Direct contact with water or any other liquid will result in product caking. Under normal circumstances, the use of this product will not cause any undue health hazards. Precautions must be taken to prevent solid or liquid product to contact with skin or eyes.

Customization Service
R&D and Production: We specializes in the development of functional materials and has provided a number of development and improvement solutions.
Granular Production: Our granulation and superfine pulverization can improve bulk density to filling capsules and tablets. and increase water solubility.
Blending and Mixing