L-5-Methyltetrahydrofolate Calcium Nutritional Supplement High Quality CAS No 151533-22-1

Product Details
Customization: Available
Function: Vitamins and Minerals Deficiency Drug, Antibiotic and Antimicrobial Agents
Certification: GMP
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Plant Area
501~1000 square meters
Management System Certification
ISO 9001
  • L-5-Methyltetrahydrofolate Calcium Nutritional Supplement High Quality CAS No 151533-22-1
  • L-5-Methyltetrahydrofolate Calcium Nutritional Supplement High Quality CAS No 151533-22-1
  • L-5-Methyltetrahydrofolate Calcium Nutritional Supplement High Quality CAS No 151533-22-1
  • L-5-Methyltetrahydrofolate Calcium Nutritional Supplement High Quality CAS No 151533-22-1
  • L-5-Methyltetrahydrofolate Calcium Nutritional Supplement High Quality CAS No 151533-22-1
  • L-5-Methyltetrahydrofolate Calcium Nutritional Supplement High Quality CAS No 151533-22-1
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Basic Info.

Model NO.
L-5-Methyltetrahydrofolate calcium
Grade Standard
Food Grade
Type
Analysis reagent
State
Liquid
Volatile
Not Volatile
CAS
151533-22-1
Transport Package
25kg
Specification
99%
Trademark
langyue
Origin
Hunan
HS Code
2901
Production Capacity
30 Tons/Year

Product Description

Product Information:

Product Name:
Levomefolate calcium
Synonyms:
(S)-2-(4-((((S)-2-AMino-5-Methyl-4-oxo-3,4,5,6,7,8-hexahydropteridin-6-yl)Methyl)aMino)benzaMido)pentanedioic acid, calciuM salt;
L-5- Methyl leucovorin;Calcium (S)-2-(4-((((S)-2-amino-5-methyl-4-oxo-3,4,5,6,7,8-hexahydropteridin-6-yl)methyl)amino;
CALCIUML-5-METHYLTETRAHYDROFOLATE;
(6S)-N-[4-(2-Amino-1,4,5,6,7,8,-hexahydro-5-methyl-4-oxo-6-pteridinylmethylamino)benzoyl]-L-glutaminsure, Calciumsalz (1:1);
Calcium levomefolate;L-5-Methyltetrahydrofolate calcium;METHYL FOLATE CALCIUM SALT(METAFOLIN)(P)
CAS:
151533-22-1
MF:
C20H27CaN7O6
MW:
501.56
EINECS:
691-636-3
Levomefolate calcium is an organic calcium salt of (6S)-5-methyltetrahydrofolic acid. It has a role as an antidepressant. It
contains a (6S)-5-methyltetrahydrofolate(2-).
ITEM
SPECIFICATION
RESULT
Test method
Appearance
White to light yellow crystalline powder
Complies
Visual
Identification
IR
IR should be identical with that of reference
Complies
USP43
 
Calcium
A 5-mg/mL solution meets the requirements
 
 
 
HPLC
The retention time of the major peak in the chromatograme of Assay preparation corresponds to
that in the chromatograme of the standard preparation, as obtained in the Assay
 
 
Elemental impuritiys
Boron
≤50PPM
Complies
USP43
 
Platinum
≤10PPM
Complies
 
 
Arsenic
≤1.5PPM
Complies
 
 
Cadmium
≤0.5PPM
Complies
 
 
Lead
≤1.0PPM
Complies
 
 
Hg
≤1.5PPM
Complies
 
Residual solvent
Ethanol≤0.5% 2-Propanol≤0.5%
Complies
USP43
Related compounds
4-Aminobenzoylgluta mic acid
≤0.5%
ND
USP43
 
4a-Hydroxy-5-methyl-tetrahydrofolic acid
≤1.0%
ND
 
 
(6R)-Mefox
/
ND
 
 
(6s)-Mefox
≤1.0%(sum of 6R and 6S)
0.31%
 
 
Tetrahydrofolic acid
≤0.5%
ND
 
 
7,8-Dihydrofolic acid
≤0.5%
ND
 
 
Folic acid
≤0.5%
ND
 
 
5,10-Methylenetetrah-yd rofolic acid
≤0.5%
ND
 
 
5-Methyltetrahydrop-teroic acid
≤0.5%
ND
 
 
Dimethyltetrahydrofolic acid
≤0.15%
ND
 
 
Total Impurites
≤2.5%
1.21%
 
D-5-Methylfolate
≤1.0%
0.24%
USP43
Calcium (on the anhydrous and solvent-free basis)
7.0%-8.5%
7.8%
USP43
Water determination
6%-17.0%
16.3%
Karl Fischer
Particle size
90% pass 80 mesh
Complies
Sieve
Chloride
≤0.5%
Complies
USP43
Heavy metals
≤10ppm
Complies
USP43
Total microbacterial count
≤100CFU/g
Complies
CP2015
Yeast &Mould
≤10CFU/g
Complies
CP2015
Escherichia Coli presence
Negative
Negative
CP2015
Salmonella
Negative
Negative
CP2015
Staphylococcus aureus
Negative
Negative
CP2015
P. aeruginosa
Negative
Negative
CP2015
Candida albicans
Negative
Negative
CP2015
Clostridia
Negative
Negative
CP2015
Calcium L-5-methyltetrahydrofolate
95.0%-102.0%
98.9%
USP43
L-5-methyltetrahydrofolate
≥85.0%
90.1%
USP43
Conclusion
The results conforms with the USP43 standard.
 
Uses:
  • Mainly for folic acid antagonists (such as methotrexate, pyrimethamine, benzyl cefalexin and trimethoprim) antidote, it's usually used for prevention of methotrexate dose or overdose treatment caused severe toxic effects.
  • Folic acid treatment of the following diseases, such as inflammatory diarrhea and protein-energy malnutrition (poor nutrition), pregnancy or infancy megaloblastic anemia caused by poor.
  • As adjuvant therapy for colon cancer, rectal cancer.
  • Combined with 5-FU and treatment of digestive tract tumors or other 5-FU-sensitive tumors. High-dose CF used in conjunction with 5-FU (LF), the basic programme is currently the treatment of colon and rectal cancer.
  • For children with leukemia, lymphoma, and osteosarcoma, such as high dose MTX treatment when rescued.  
 
Quality Control: 
We have advanced precision instruments and equipment ,so we can independently control product content, pesticide residue, physical and chemical properties, microorganisms, heavy metals and other quality indicators. Our goal is zero complaints.
L-5-Methyltetrahydrofolate Calcium Nutritional Supplement High Quality CAS No 151533-22-1


We have our own plant base. Weeding by hand, no pesticides or herbicides used. Control quality from the source.
L-5-Methyltetrahydrofolate Calcium Nutritional Supplement High Quality CAS No 151533-22-1




Packaging:
The product is packed in 25kg or 10kg fiber drum.
It should be stored in its original packing or in a suitable sealed container and kept in a clean and dry place. Storage conditions should preferably be a sheltered environment with limited temperature variations and low humidity levels. Direct contact with water or any other liquid will result in product caking. Under normal circumstances, the use of this product will not cause any undue health hazards. Precautions must be taken to prevent solid or liquid product to contact with skin or eyes.

Customization Service
R&D and Production: We specializes in the development of functional materials and has provided a number of development and improvement solutions.
Granular Production: Our granulation and superfine pulverization can improve bulk density to filling capsules and tablets. and increase water solubility.
Blending and Mixing
 

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