Tranexamic acid
CAS:1197-18-8
Molecular Formula:C8H15NO2
Molecular Weight:157.21
Tranexamic acid:White crystalline powder; odorless, slightly bitter taste.
Solubility of tranexamic acid: soluble in water, almost insoluble in ethanol, ace-tone, chloro-form or ether.
Usage: pharmaceutical raw material, coagulant; medicine, daily chemical, whitening and freckle removing material.
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Tranexamic acid is a synthetic derivative of lysine and is a commonly used hemostatic drug in clinical practice. It exerts hemostatic effects by inhibiting the dissolution of fibrin. Tranexamic acid can strongly adsorb the lysine binding site (LBS) of the fibrin affinity site on plasmin and plasmin, which inhibits the binding of plasmin, plasmin and fibrin, thus strongly inhibiting the fibrinolysis caused by plasmin; In addition, in the presence of anti fibrinolytic enzymes such as macroglobulin in the serum, the anti fibrinolytic effect of tranexamic acid is more pronounced. Its bioavailability is 34% and its half-life is 3.1 hours.
pharmacological action
Carbamate, also known as tranexamic acid, chemical name 4-aminomethylcyclohexanecarboxylic acid, and trade name Chemicalbook Seramine. Tranexamic acid is a synthetic amino acid antifibrinolytic drug, which can competitively inhibit the combination of lysine of fibrin and plasmin, thus inhibiting the lysis of fibrin clots and producing hemostasis. It is mainly used clinically for various bleeding caused by fibrinolysis hyperactivity. Tranexamic acid is a synthetic lysine analog that can competitively bind plasmin to the lysine binding site on plasmin, thereby competitively inhibiting the degradation of fibrin, reducing fibrinolytic activity and playing a role in promoting blood coagulation. In theory, the use of tranexamic acid can lead to insufficient fibrinolytic activity, which in turn may increase the risk of postoperative thrombotic events.
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